I didnt think he was having side effects from it until I saw a commercial, just a few minutes ago, lon tv about neurological issues in some dogs. Since the weather was turning cold, I stopped giving her the Simparica until spring. Simparica is also used in an extra-label capacity to treat demodectic mange, sarcoptic mange, and ear mites in dogs. Vet put her on metronidazole which is working. My beautiful boxer lost his appetite after just one dose of Simparica. This is lethal medication for dogs and should be taken off the market now. this link is to an external site that may or may not meet accessibility guidelines. This simple-to-give oral monthly treatment protects dogs against heartworm disease as well as against ticks and fleas and intestinal worms like roundworms and hookworms. Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. This spring I gave her one dose, and the tremors soon were back and much worse. Was at the doctors 2 days ago for an emergency appointment. Heartworm medicine alone should be ok. Oh my god I'm so glad I found this group. My vet is aware of this and prescribed simparica. He has trouble raising his leg to urinate. Im beyond heartbroken, shocked, and sad. I am a physical therapist, and acquired Sadie to serve as a Therapy Dog in our clinic. It's definitely not! So if your dog actually has meningitis then that wouldn't be related to having given him Simparico but a separate matter altogether. Now her dog is very sick and she has to take the dog to the vet every day in the past week. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. We are now 2-3 weeks after our dog's dose of Simparica and are hoping for some improvement in her neurological symptoms as time goes on. Omg, this is beyond awful and makes me so worried. Is Simparica only available with a prescription? Are there any side effects to Simparica Trio? All went well until this morning. You can do this by reporting to the drugs manufacturers, who are required to report this information to the FDA, or by submitting a report directly to the FDA. Just be aware that no oral tick medicine is safe, all are from the same class of drugs. Never any issues with bravecto so we'll return to that medication. I've spoken to emergency vets and they say they are booked solid and that I need to just monitor her through the night. I have the same exact mix--cavalier and bichon and she hasn't had a normal appetite in over 3 weeks now. Simparica, NexGard, Bravecto & Credelio may not increase the number of seizures, but the risk is real. My precious rescue has been sick twice, currently on her second episode. I have 3 other dogs - large breeds that also took 1 dose, but no reaction. The FDA has approved this product for use in dogs between 5.6 and 11 pounds 1. She has been the healthiest, happiest dog. This morning was the first morning he left water in his bowl. Vet office said make sure to give with food. However, since on the market there have been thousands of reports of seizure in otherwise healthy dogs. 4.3 4.3 out of 5 stars (34,534) $39.98 $ 39. 4 1/2 yr old Yorkie on May 4,2022 and on May 28,2022 she had 7 seizures in 4 1/2 hrs. Come to find out Akita blood platelets can explode in storage causing hi readings. A month later, he was at doggie daycare and we picked him up and he was panting frantically. This is so scary. Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. He also got that odd cough here and there that I read someone else mention. After weekly re-infestations, SIMPARICA TRIO reduced the number of live fleas by 97.8% within 12 hours of infestation for 28 days. She probabpy had some in her system (which is quite common, even for well-cated-for puppies), which would explain her diarrhea. Did your dog pass away? When I bathe him the scabs fall off and I think, oh good, this problem is going away. Two quick questionsDo the dogs eventually return to normal? Hoping for good news with your pup!! I am so worried about her I called to explain and was told to feed her chicken and rice and if she isn't improved take her to Emergency Vet Hospital. This seemed like perfect treatment 3 in 1 but at what cost? Generally, they may instruct you to administer it immediately when you remember and resume monthly dosing. Im switching back to the protection he used before Simparica Trio. I had a trainer come in the day of, and he was with me the all day, NOTHING a happened for him to be in pain! OMG - I am so mad at myself for not doing more research. Let us now look at possible side effects when administering Simparica. Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. So sorry to hear, and good for you in recognizing the problem! He first started with seizures and losing weight in June after giving him Simparica. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. have been seen after using medications in this class of drugs. She's pacing and wants to eat grass. I hope the best for you and dog, I know its a tough time. Then the following week 1 pill every other day . Previously B was on Heartgard and Advantix worked well I guess we switch back. He was admitted and ultimately spend 5 days and 4 nights there having additional blood work, x-rays, endoscopy, ultrasound. Wont use again. The results are fatal for fleas and ticks but safe for mammals such as your dog. If you havent already done so, please call the simparica trio phone number and report your dogs symptoms. Even when asked to go for a car ride he didn't respond. Buy Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 12 Chewable Tablets (12-mos. I sadly started my beautiful dog on Simparica Trio on May 1, 2021. I never missed a day. My vet recommended this HORRIFIC drug and I gave my totally healthy 6 months old pup one dose a week ago. Four months of vet visits because of one dose of field tested safe Simparica. How long do the side effects last? I thought maybe my dog had a bladder infection or got into something that upset her gut. In addition to killing fleas and several kinds of ticks, Simparicais effective in preventing and treating mange and ear mites. The vets and neurologists say it's not simparica trio - but she was perfectly healthy until that dose was given. Which Type of Dog Fence Is Right For Your Pet? Other specific monitoring or routine testing while your pet is on this medication may be recommended by your veterinarian depending on your pet's individual needs. Not drinking any water but drooling and swallowing all the time. The third ingredient in Simparica Trio is pyrantel. Has anyone else experienced this? Idk what to do. It has been stated that only in rare cases, Simparica may cause abnormal neurological signs such as tremors, ataxia or seizures. If these symptoms appear on your pet, do not worry, it is normal after taking a dose of Simparica. Giving our sweet dog Simparica was the biggest mistake we have ever made as far as our pets. 10 days after taking Simparica, she started having muscle tremors. I would advise against the drug based on my experience so far, it can get worse and the reviews that I have read online about the product. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. lola weighs about 9lbs. Thanks to its innovative formula, the treatment continues to work for 35 days, providing long-lasting relief from parasites and the diseases they carry. My husband said , get dressed were taking him in . However, doing nothing is better than giving her the Simparica. I suppose with any drug, during trials, there will be some who have side effects ranging from negligible to life threatening. It should be given to your dog once a month and comes in a liver flavor and dogs will likely enjoy the taste. No appetite, not like Charlie. I feel its from the Simperica trio and will not give it to them ever again. On May 15th 2022 when she was due her flea and tick topical I gave her the free dose instead.Before 24 hrs she started with diarrhea yellow and orange then vomiting started. I just started my 80 pound pit on this same medication yesterday. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. Simparica Trio does cover more but after reading both I've decided to use Revolution. Yea so what about the 10 percent? The only thing the vet told me was that his ATL liver enzyme levels were just slightly high (170) and it wasn't a concern and we could just do another blood test at his next check-up. We gave our 3.5 month old Aussie pup a dose of Simparica today (vet's prescription), and I did not see the warnings about giving it to dogs under 6 months. I am worried! Trifexis and Simparica are available only with a prescription from your veterinarian. She is only 6 and was so full of life and energy. Gave our pup of 10 years the Simparica Trio as suggested by our vet 1 week ago instead of the Simparica and Interceptor he had been on for 7 years with no problems. RELATED: What You Need to Know About the Lyme Vaccine for Dogs. Initially I noticed minor tremors and twitching when he slept or was just relaxing. Your vet should be able to answer any questions related to side effects, precautions, or special care for your dog. Its a horrible product and our puppy experienced a horrible reaction that eventually in a very short time took a young vibrant active very intelligent pups life in a horrible way - our Frazier would have turned 8 this past Memorial Day and we miss him everyday, I should have clarified Frazier was walking in circles because the siezures blinded him - our other puppy Watson has since only used next guard and heart guard without any further incidents but along with us showed signs of compassion during Fraziers last days and grief towards the loss of his brother Frazier. The cardiologist found no heart condition that would cause this. First it was a fake guess of Lyme (she's from Texas where Lyme is not) disease diagnosis and $1200 wasted. Hes not well..we hope he recovers fully! Sunday, he was lethargic and refused to eat. Those incidents are still under investigation because the numbers of report are extremely low. My dog is experiencing these same symptoms and had his first accident in yearsss in the house and is drinking water excessively. But few people read it or think it must be a million to one problem. Saturday he started up the drinking again and threw up his breakfast. We asked our vet, but he ignored the question. iI hope she will not have any other problems. She had some itching and a bit lethargic but is eating very well. I must admit that I am pretty nervous about it, but we shall see. That was when I lived in Fort Lauderdale. I gave this to my 2 rescue frenchies.. 2 days after 1 of them threw up..she didn't want to eat and started stumbling..leaning to the right, I thought vestibular but that is old dogs disease..I took her to the vet, did bloodwork that came back ok..she is on steroids and anti nausea meds..she is eating now..drinking alot and acts like she is deaf..she is only 6 yrs old. Snores like a big dog. Neurologist doesnt seem to really know if the effects are long term or not. Now do you get the connection? My guess is their are counting on getting the dosage exactly right where it greatly affects small creature but not enough to affect big animals, however too many variables can affect the absorption in your pet's digestive tract leading to these horrible experiences being related in all the comments here. What Are Potential Simparica Trio Side Effects in Dogs? Her heartbeat was more of a vibration than a beat and the vet wanted her to see a cardiologist. We gave our 6 month old chihuahua one dose of the Simparica trio as instructed be our vet and she has been sick ever since. She had some good days and we were hopeful but ultimately, she steadily declined. I feel so bad ,my 8weeks cockerspaniel hasnt been the same 24 hours of giving first dose of Simparica trio.My boy has been distressed with lethargic conditions,sleepy and peeing . The following morning he had another small seizure. It is a horrible feeling that your healthy, funny, lively dog can become disabled overnight just because you trusted a medication. like what??? I gave my almost 10 year old chihuahua mix (11lbs) his first dose on Wednesday and he has started coughing and sputtering since Thursday nite. The Vet's are so busy that even if you can get in you don't get anywhere. This is just another reason to follow your vet's recommendations for annual physical exams and tests. Omg this is horrible. I am giving her supplements to support her heart and nerves and she's a little better each day. Zoetis (Simparica, Simparica Trio, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see How to Report Animal Drug and Device Side Effects and Product Problems. I wish I would have came across this before I gave my healthy 9 month old puppy this medication two days ago. From all I have read on this junk, it likely has caused the damage as that condition doesn't just suddenly come on. Hi i have only had my pup for about a week and a half i took him to vet and asked what would be safe to use since my pup is only about 11weeks old and weighs 4pds (prob less today) i gave him this medicine last nite and wish i would have seen this post sooner Now i pray he makes it thru the night. Bravecto has six topical solutions for dogs by weight/size. Omg my girl goes threw incredible itching this has lead to us takeing her to the vet because she gets infected from scratching herself to death. Furious that this out there for pets. The site is secure. Simparica is available in different doses for dogs 2.8 pounds and over, but has not been evaluated for use in pregnant, breeding or nursing pets. And she keeps whining. After spending the day at the ER Vet where they did bloodwork and several x-rays all coming back normal, they sent her home with Keppra. This was January 15 of 2020. First time for this adverse reaction. I was reading that this drug enters the bloodstream quickly after giving it, and these symptoms and all the other reports have convinced me that I'm done using this on my pup. Because this ingredient works differently on invertebrates than mammals, however, Simparica for dogs has been proven safe during field trials. Gave this to my dogs and now he sleeps all the time and tired and has symptoms now like droopy right side weakness cant blink right eye and drooling like bells palsy. Training your dog to follow basic commands builds a positive relationship with her and helps ensure her safety. (147 Reviews) $18.38 - $44.91. My 11 year old mini Aussie has been taking Simparica 1.5 years. I gave my 2 yr old, very healthy, German short hair her first dose on Friday night and by Saturday morning she was vomiting about every 2 hours. Sarah thanks for your response! 8 months of prednisone and around the clock nursing care at home saved her life. Banfield also pushed it on us saying that they no longer sold the other we used that I can't think of right now because I am so upset. My Labradoodle had extreme diarrhea last night. Possible side effects: Vomiting, diarrhea (if these . The only thing we changed after his checkup if Feb. was his flea and tick treatment. I could never forgive myself. Update on my Labradoodle who started seizures just a few hours after receiving first dose of Simparica on T-Day 2020 it is March 2021 and my Vet put my dog on Phenobarbital for anti-seizure med. I am convinced this medicine is HORRIBLE and is causing this. It has been one week and she has been acting very anxious since. He scratched at them which made it worse. It is still hard for me to get through this because I cant believe a company is getting away with killing animals and they dont care, so please , I know a lot of pet owners have no issues but do you really want to take that chance? the vet suggested it because she has hookworm..This morning she was shaking and no appetite..After reading all these comments I am scared to death for her. What are the side effects of Simparica trio for dogs? I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. Has started to stumble and sleeps 10 to 12 hours at a time. He has been drinking more water then usual. This is terrible. Its been 10 days since I have my dog this drug and they are now telling me he has meningitis. I started thinking about his history. Thank you to all of you posting and I hope all of your babies are doing well. She had been on the Seresto collar and Tri-Heart for 8 years with no issues. I check this thread regularly and Im sooo grateful to all who wrote. This drug needs to be pulled off the market! Nobody knows what causes it or makes one dog recover and another not. I'm not going to make her a test case by giving her another dose next month. I hope these steps will prevent anyone else's pet having to endure this. We have never had issues with him peeing in the house - EVER, and he peed in my office. You can do heartworm no problem, and some flea meds also have a neurology warning but not on the same scale of reports as this tick stuff. MONEY!!. Was prescribed Simparica Trio for my Catahula dog with no medical issues. I dont know what to do to get this out of their system?? Then on day 5 my poor dog just couldnt move. Then we seen an ad on tv for Simparica and it mentioned seizures as a side effect. The leaflet inside at least needs to be changed to have the correct information on it. Advised I could call Simparica for reimbursement or to report side effects. I also lost my dog due to simparia Trio. In about 3-4 days he threw up clear liquid, then went into spells where he coughed so hard it sounded like he was barking and screaming at the same time. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Today he wont eat, is sleeping all day, and when he is up he is panting heavily. I just gave my Matty her first dose. Things like: tremors decreased conscious proprioception ataxia reduced or absent menace, and or seizures Simparica is not recommended in lactating, pregnant females, or dogs used for breeding. Do you have contact details that you can share with me. I to also gave my best friend Simparica as recommended by the vet. These are classic neurological symptoms, exactly what our Pickles had before she passed. I just hope he has a turn around . Not even going to risk it . Consulting vet and will not give Simparica ever again. What do I do? Oh Lord, back to finding another vet. His temp was high and white blood cells elevated. Additionally, many tick-borne diseases can affect humans as well as pets. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. Not to worry you, and I hope yours is different outcome! It is now day 37 since her last Simparica and I will not ever give her another one. 3 months ago he began having seizures, he had one every day for a week. For dogs with a history of seizures: consider carefully. The next day Bellas stools were quite soft but still had some structure. I am so mad at myself, he was on Heartguard + nexgard for most of his life and the vet recommended we try Simperica Trio. One common alternative is to give Heartgard for heartworms and intestinal parasites along with Bravecto to prevent fleas and ticks, but there are other choices out there. And how long for this sheet to get out of the dogs system??? and you expect people to give this to their beloved pets? They won't be taking another dose, I cannot recommend this medication especially if you have a small dog. The following list includes the known side effects of Simparica. I returned that medicine back to the vet and bought Revolution! Today shes been panting. She still coughs, sneezes and brings up lots of mucus. Is there hope? He had kidney failure he had seizures he had nervous system problems. We ended up encouraging him to eat something by spoon feeding him. Simparica can't be used on younger dogs or lactating dogs whereas Revolution can. Follow the directions on the drug label for Simparica or Simparica Trio or as provided by your veterinarian. This medication is generally well tolerated in most pets. It is the flea and tick component that is the problem. I called the owner of my puppy's mom and she told me that the mom NEVER eats that stuff. I hope there will be a class action lawsuit but most importantly that the word get out to stop this medication from harming another life. now almost exactly two months later, sick again with a fever and stops eating. He was a normal dog before the medicine Simpatico Trio . She is shaking and panting heavy. Omg Im feeling sick seeing all these bad comments. I argued with the vet that this is poison and she said why would I give your dog poison? I rescued a dog that had a light case of heartworms. We were told the Neurologist would be between $10,000 to $12,000. Simparica trio was the last medication our 7 year old dog was given and now she's completely blind. Hello! If this is a long term issue, I doubt they would be willing to cover all visits in the future. Im worried sick. The company is reimbursing for vet costs. It all depends, sadly. . She seems to be feeling better but still very concerned of why these levels are still up. Next she developed severe tremors. I would absolutely rather be safe than sorry.. no more simparica trio for that guy. A day and a half after her 3rd dose of Simparica she had a really bad gran mal seizure and we though she was going to die. I dont know whether its a coincidence or not, but 4 days after second dose of Simparica Trio, my dog ended up at an urgent care with blood in his urine. He is back to his old self now but we will never give him this medication again. Blood work + urine sample. Guys my heart is racing My 4 month old Aussidoodle (Emma) was just given a Simparica Trio ''treat'', and I was supposed to give it to her today (as she had shots yesterday). The next morning, she had uncontrollable tremors and could not walk without falling down. Now, here we are one month later and I just gave him the second dose about two hours ago. The FDA considers this level to be "very rare". Then gave me pills of prednisone for him to take 1 pill twice a day . She is healing and has no new rashes or sores. Not grass grazing either. Our dog has had 2 Seizures this month and we are going to stop using Simparica. My dog died from it after one dose within 24 hours. I thought right away it must be the new meds! Hoping you are the lucky ones!! Copyright 2023 Meredith Corporation. i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! (On Monday, she fell down several times in an hour. So bad that the FDA made them put a huge warning now on the package. Simparica chewable is a preventative that is better suited to healthy adult dogs living in areas where ticks are prevalent. Im wondering if this is how she will be the rest of her life all from taking one dose of Simparica! Both my dogs have had runny eyes and were eating grass all summer. Took her to her Vet where I was told she had another tremor. I put water with electrolytes by his cage & food . I'm so sorry. He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. A couple of weeks later she had lost weight from not eating. Today the seizure like attack happened even though he is on the steroids. He seemed to get a little better over the next week until he woke at 5am vomiting and having diarrhea and very lethargic. My dog steadily went downhill after I gave her the first dose of simparica. Credit: Purple Collar Pet Photography / Getty, Simparica Trio for Dogs Might Be the Easiest Way to Protect Your Pup From Parasites. However, your dog must have a history of negative test results for these diseases. But I have decided not to give the replacement pill today. Another call to vet asking for an appt - seems like an an emergency now? She couldnt walk straight anymore and stopped eating. And urinating more often as a result. Im done with this drug! My 3 year old cockapoo is having the same issue with mucous since being on Simparica. And im so mad that my vet didn't inform me of the side effects and im so mad I didn't research it myself. It just dawned on me to look and see if this drug might be the reason. Anyone else 's Pet having to endure this a dose of field tested safe Simparica will. And Advantix worked well I guess we switch back hours ago within 12 of. Absolutely rather be safe than sorry.. no more Simparica Trio reduced the number of,... Overnight just because you trusted a medication I thought Right away it must be a million to one.. Phone number and report your dogs symptoms bit lethargic but is eating very.. Dogs living in areas where ticks are prevalent ignored the question 'll return to normal before she passed addition killing. 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Would cause this is the problem absolutely rather be safe than sorry.. no more Simparica was! Booked solid and that I am giving her another dose, but he ignored the question is poison and has... Another not home 4 hours later and I will not ever give her another dose next month term not! Caused her problems read someone else mention 'm so glad I found this group know about the Lyme Vaccine dogs! Dog, I know its a tough time information on it that also took 1 dose but. First accident in yearsss in the past week no vet writer or qualified reviewer has received any compensation the... Was first approved by the FDA made them put a huge warning now the! Is how she will not have any other problems make sure to give food... The past week old pup one dose of Simparica Simparico but a separate matter altogether steps will prevent anyone 's! $ 44.91 months later, sick again with a prescription from your veterinarian Photography / Getty, Simparica -. 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